Progranulin modulates zebrafish motoneuron development in vivo and rescues truncation defects associated with knockdown of Survival motor neuron 1
Identifieur interne : 001A00 ( Main/Exploration ); précédent : 001999; suivant : 001A01Progranulin modulates zebrafish motoneuron development in vivo and rescues truncation defects associated with knockdown of Survival motor neuron 1
Auteurs : Babykumari P. Chitramuthu [Canada] ; David C. Baranowski [Canada] ; Denis G. Kay [Canada] ; Andrew Bateman [Canada] ; Hugh Pj Bennett [Canada]Source :
- Molecular Neurodegeneration [ 1750-1326 ] ; 2010.
Abstract
Progranulin (PGRN) encoded by the
Whole-mount
Expression of PGRN within MNs and the observed phenotypes resulting from mRNA knockdown and over-expression are consistent with a role in the regulation of spinal cord MN development and branching. This study presents the first
Url:
DOI: 10.1186/1750-1326-5-41
PubMed: 20946666
PubMed Central: 2974670
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Progranulin modulates zebrafish motoneuron development <italic>in vivo </italic>and rescues truncation defects associated with knockdown of Survival motor neuron 1</title><author><name sortKey="Chitramuthu, Babykumari P" sort="Chitramuthu, Babykumari P" uniqKey="Chitramuthu B" first="Babykumari P" last="Chitramuthu">Babykumari P. Chitramuthu</name><affiliation wicri:level="1"><nlm:aff id="I1">Endocrine Research Laboratory and Department of Medicine, Royal Victoria Hospital and McGill University Health Centre Research Institute, Montreal, Quebec, H3A 1A1, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Endocrine Research Laboratory and Department of Medicine, Royal Victoria Hospital and McGill University Health Centre Research Institute, Montreal, Quebec, H3A 1A1</wicri:regionArea><wicri:noRegion>H3A 1A1</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="I2">Neurodyn Inc., Suite 508, NRC-INH, 550 University Avenue, Charlottetown, Prince Edward Island, C1A 4P3, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Neurodyn Inc., Suite 508, NRC-INH, 550 University Avenue, Charlottetown, Prince Edward Island, C1A 4P3</wicri:regionArea><wicri:noRegion>C1A 4P3</wicri:noRegion></affiliation></author><author><name sortKey="Baranowski, David C" sort="Baranowski, David C" uniqKey="Baranowski D" first="David C" last="Baranowski">David C. Baranowski</name><affiliation wicri:level="1"><nlm:aff id="I2">Neurodyn Inc., Suite 508, NRC-INH, 550 University Avenue, Charlottetown, Prince Edward Island, C1A 4P3, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Neurodyn Inc., Suite 508, NRC-INH, 550 University Avenue, Charlottetown, Prince Edward Island, C1A 4P3</wicri:regionArea><wicri:noRegion>C1A 4P3</wicri:noRegion></affiliation></author><author><name sortKey="Kay, Denis G" sort="Kay, Denis G" uniqKey="Kay D" first="Denis G" last="Kay">Denis G. Kay</name><affiliation wicri:level="1"><nlm:aff id="I2">Neurodyn Inc., Suite 508, NRC-INH, 550 University Avenue, Charlottetown, Prince Edward Island, C1A 4P3, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Neurodyn Inc., Suite 508, NRC-INH, 550 University Avenue, Charlottetown, Prince Edward Island, C1A 4P3</wicri:regionArea><wicri:noRegion>C1A 4P3</wicri:noRegion></affiliation></author><author><name sortKey="Bateman, Andrew" sort="Bateman, Andrew" uniqKey="Bateman A" first="Andrew" last="Bateman">Andrew Bateman</name><affiliation wicri:level="1"><nlm:aff id="I1">Endocrine Research Laboratory and Department of Medicine, Royal Victoria Hospital and McGill University Health Centre Research Institute, Montreal, Quebec, H3A 1A1, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Endocrine Research Laboratory and Department of Medicine, Royal Victoria Hospital and McGill University Health Centre Research Institute, Montreal, Quebec, H3A 1A1</wicri:regionArea><wicri:noRegion>H3A 1A1</wicri:noRegion></affiliation></author><author><name sortKey="Bennett, Hugh Pj" sort="Bennett, Hugh Pj" uniqKey="Bennett H" first="Hugh Pj" last="Bennett">Hugh Pj Bennett</name><affiliation wicri:level="1"><nlm:aff id="I1">Endocrine Research Laboratory and Department of Medicine, Royal Victoria Hospital and McGill University Health Centre Research Institute, Montreal, Quebec, H3A 1A1, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Endocrine Research Laboratory and Department of Medicine, Royal Victoria Hospital and McGill University Health Centre Research Institute, Montreal, Quebec, H3A 1A1</wicri:regionArea><wicri:noRegion>H3A 1A1</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">20946666</idno><idno type="pmc">2974670</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2974670</idno><idno type="RBID">PMC:2974670</idno><idno type="doi">10.1186/1750-1326-5-41</idno><date when="2010">2010</date><idno type="wicri:Area/Pmc/Corpus">000A34</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000A34</idno><idno type="wicri:Area/Pmc/Curation">000A34</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000A34</idno><idno type="wicri:Area/Pmc/Checkpoint">000A22</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000A22</idno><idno type="wicri:Area/Ncbi/Merge">000D57</idno><idno type="wicri:Area/Ncbi/Curation">000D57</idno><idno type="wicri:Area/Ncbi/Checkpoint">000D57</idno><idno type="wicri:Area/Main/Merge">001B06</idno><idno type="wicri:Area/Main/Curation">001A00</idno><idno type="wicri:Area/Main/Exploration">001A00</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Progranulin modulates zebrafish motoneuron development <italic>in vivo </italic>and rescues truncation defects associated with knockdown of Survival motor neuron 1</title><author><name sortKey="Chitramuthu, Babykumari P" sort="Chitramuthu, Babykumari P" uniqKey="Chitramuthu B" first="Babykumari P" last="Chitramuthu">Babykumari P. Chitramuthu</name><affiliation wicri:level="1"><nlm:aff id="I1">Endocrine Research Laboratory and Department of Medicine, Royal Victoria Hospital and McGill University Health Centre Research Institute, Montreal, Quebec, H3A 1A1, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Endocrine Research Laboratory and Department of Medicine, Royal Victoria Hospital and McGill University Health Centre Research Institute, Montreal, Quebec, H3A 1A1</wicri:regionArea><wicri:noRegion>H3A 1A1</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="I2">Neurodyn Inc., Suite 508, NRC-INH, 550 University Avenue, Charlottetown, Prince Edward Island, C1A 4P3, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Neurodyn Inc., Suite 508, NRC-INH, 550 University Avenue, Charlottetown, Prince Edward Island, C1A 4P3</wicri:regionArea><wicri:noRegion>C1A 4P3</wicri:noRegion></affiliation></author><author><name sortKey="Baranowski, David C" sort="Baranowski, David C" uniqKey="Baranowski D" first="David C" last="Baranowski">David C. Baranowski</name><affiliation wicri:level="1"><nlm:aff id="I2">Neurodyn Inc., Suite 508, NRC-INH, 550 University Avenue, Charlottetown, Prince Edward Island, C1A 4P3, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Neurodyn Inc., Suite 508, NRC-INH, 550 University Avenue, Charlottetown, Prince Edward Island, C1A 4P3</wicri:regionArea><wicri:noRegion>C1A 4P3</wicri:noRegion></affiliation></author><author><name sortKey="Kay, Denis G" sort="Kay, Denis G" uniqKey="Kay D" first="Denis G" last="Kay">Denis G. Kay</name><affiliation wicri:level="1"><nlm:aff id="I2">Neurodyn Inc., Suite 508, NRC-INH, 550 University Avenue, Charlottetown, Prince Edward Island, C1A 4P3, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Neurodyn Inc., Suite 508, NRC-INH, 550 University Avenue, Charlottetown, Prince Edward Island, C1A 4P3</wicri:regionArea><wicri:noRegion>C1A 4P3</wicri:noRegion></affiliation></author><author><name sortKey="Bateman, Andrew" sort="Bateman, Andrew" uniqKey="Bateman A" first="Andrew" last="Bateman">Andrew Bateman</name><affiliation wicri:level="1"><nlm:aff id="I1">Endocrine Research Laboratory and Department of Medicine, Royal Victoria Hospital and McGill University Health Centre Research Institute, Montreal, Quebec, H3A 1A1, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Endocrine Research Laboratory and Department of Medicine, Royal Victoria Hospital and McGill University Health Centre Research Institute, Montreal, Quebec, H3A 1A1</wicri:regionArea><wicri:noRegion>H3A 1A1</wicri:noRegion></affiliation></author><author><name sortKey="Bennett, Hugh Pj" sort="Bennett, Hugh Pj" uniqKey="Bennett H" first="Hugh Pj" last="Bennett">Hugh Pj Bennett</name><affiliation wicri:level="1"><nlm:aff id="I1">Endocrine Research Laboratory and Department of Medicine, Royal Victoria Hospital and McGill University Health Centre Research Institute, Montreal, Quebec, H3A 1A1, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Endocrine Research Laboratory and Department of Medicine, Royal Victoria Hospital and McGill University Health Centre Research Institute, Montreal, Quebec, H3A 1A1</wicri:regionArea><wicri:noRegion>H3A 1A1</wicri:noRegion></affiliation></author></analytic><series><title level="j">Molecular Neurodegeneration</title><idno type="eISSN">1750-1326</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Progranulin (PGRN) encoded by the <italic>GRN </italic>gene, is a secreted glycoprotein growth factor that has been implicated in many physiological and pathophysiological processes. PGRN haploinsufficiency caused by autosomal dominant mutations within the <italic>GRN </italic>gene leads to progressive neuronal atrophy in the form of frontotemporal lobar degeneration (FTLD). This form of the disease is associated with neuronal inclusions that bear the ubiquitinated TAR DNA Binding Protein-43 (TDP-43) molecular signature (FTLD-U). The neurotrophic properties of PGRN <italic>in vitro </italic>have recently been reported but the role of PGRN in neurons is not well understood. Here we document the neuronal expression and functions of PGRN in spinal cord motoneuron (MN) maturation and branching <italic>in vivo </italic>using zebrafish, a well established model of vertebrate embryonic development.</p></sec><sec><title>Results</title><p>Whole-mount <italic>in situ </italic>hybridization and immunohistochemical analyses of zebrafish embryos revealed that zfPGRN-A is expressed within the peripheral and central nervous systems including the caudal primary (CaP) MNs within the spinal cord. Knockdown of zfPGRN-A mRNA translation mediated by antisense morpholino oligonucleotides disrupted normal CaP MN development resulting in both truncated MNs and inappropriate early branching. Ectopic over-expression of zfPGRN-A mRNA resulted in increased MN branching and rescued the truncation defects brought about by knockdown of zfPGRN-A expression. The ability of PGRN to interact with established MN developmental pathways was tested. PGRN over-expression was found to reverse the truncation defect resulting from knockdown of Survival of motor neuron 1 (smn1). This is involved in small ribonucleoprotein biogenesis RNA processing, mutations of which cause Spinal Muscular Atrophy (SMA) in humans. It did not reverse the MN defects caused by interfering with the neuronal guidance pathway by knockdown of expression of NRP-1, a semaphorin co-receptor.</p></sec><sec><title>Conclusions</title><p>Expression of PGRN within MNs and the observed phenotypes resulting from mRNA knockdown and over-expression are consistent with a role in the regulation of spinal cord MN development and branching. This study presents the first <italic>in vivo </italic>demonstration of the neurotrophic properties of PGRN and suggests possible future therapeutic applications in the treatment of neurodegenerative diseases.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Bhandari, V" uniqKey="Bhandari V">V Bhandari</name></author><author><name sortKey="Palfree, Rg" uniqKey="Palfree R">RG Palfree</name></author><author><name sortKey="Bateman, A" uniqKey="Bateman A">A Bateman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bateman, A" uniqKey="Bateman A">A Bateman</name></author><author><name sortKey="Bennett, Hp" uniqKey="Bennett H">HP Bennett</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Diaz Cueto, L" uniqKey="Diaz Cueto L">L Diaz-Cueto</name></author><author><name sortKey="Gerton, Gl" uniqKey="Gerton G">GL Gerton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Daniel, R" uniqKey="Daniel R">R Daniel</name></author><author><name sortKey="Daniels, E" uniqKey="Daniels E">E Daniels</name></author><author><name sortKey="He, Z" uniqKey="He Z">Z He</name></author><author><name sortKey="Bateman, A" uniqKey="Bateman A">A Bateman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Qin, J" uniqKey="Qin J">J Qin</name></author><author><name sortKey="Diaz Cueto, L" uniqKey="Diaz Cueto L">L Diaz-Cueto</name></author><author><name sortKey="Schwarze, Je" uniqKey="Schwarze J">JE Schwarze</name></author><author><name sortKey="Takahashi, Y" uniqKey="Takahashi Y">Y Takahashi</name></author><author><name sortKey="Imai, M" uniqKey="Imai M">M Imai</name></author><author><name sortKey="Isuzugawa, K" uniqKey="Isuzugawa K">K Isuzugawa</name></author><author><name sortKey="Yamamoto, S" uniqKey="Yamamoto S">S Yamamoto</name></author><author><name sortKey="Chang, Kt" uniqKey="Chang K">KT Chang</name></author><author><name sortKey="Gerton, Gl" uniqKey="Gerton G">GL Gerton</name></author><author><name sortKey="Imakawa, K" uniqKey="Imakawa K">K Imakawa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Desmarais, Ja" uniqKey="Desmarais J">JA Desmarais</name></author><author><name sortKey="Cao, M" uniqKey="Cao M">M Cao</name></author><author><name sortKey="Bateman, A" uniqKey="Bateman A">A Bateman</name></author><author><name sortKey="Murphy, Bd" uniqKey="Murphy B">BD Murphy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="He, Z" uniqKey="He Z">Z He</name></author><author><name sortKey="Ong, Ch" uniqKey="Ong C">CH Ong</name></author><author><name sortKey="Halper, J" uniqKey="Halper J">J Halper</name></author><author><name sortKey="Bateman, A" uniqKey="Bateman A">A Bateman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhu, J" uniqKey="Zhu J">J Zhu</name></author><author><name sortKey="Nathan, C" uniqKey="Nathan C">C Nathan</name></author><author><name sortKey="Jin, W" uniqKey="Jin W">W Jin</name></author><author><name sortKey="Sim, D" uniqKey="Sim D">D Sim</name></author><author><name sortKey="Ashcroft, Gs" uniqKey="Ashcroft G">GS Ashcroft</name></author><author><name sortKey="Wahl, Sm" uniqKey="Wahl S">SM Wahl</name></author><author><name sortKey="Lacomis, L" uniqKey="Lacomis L">L Lacomis</name></author><author><name sortKey="Erdjument Bromage, H" uniqKey="Erdjument Bromage H">H Erdjument-Bromage</name></author><author><name sortKey="Tempst, P" uniqKey="Tempst P">P Tempst</name></author><author><name sortKey="Wright, Cd" uniqKey="Wright C">CD Wright</name></author><author><name sortKey="Ding, A" uniqKey="Ding A">A Ding</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kessenbrock, K" uniqKey="Kessenbrock K">K Kessenbrock</name></author><author><name sortKey="Frohlich, L" uniqKey="Frohlich L">L Frohlich</name></author><author><name sortKey="Sixt, M" uniqKey="Sixt M">M Sixt</name></author><author><name sortKey="Lammermann, T" uniqKey="Lammermann T">T Lammermann</name></author><author><name sortKey="Pfister, H" uniqKey="Pfister H">H Pfister</name></author><author><name sortKey="Bateman, A" uniqKey="Bateman A">A Bateman</name></author><author><name sortKey="Belaaouaj, A" uniqKey="Belaaouaj A">A Belaaouaj</name></author><author><name sortKey="Ring, J" uniqKey="Ring J">J Ring</name></author><author><name sortKey="Ollert, M" uniqKey="Ollert M">M Ollert</name></author><author><name sortKey="Fassler, R" uniqKey="Fassler R">R Fassler</name></author><author><name sortKey="Jenne, De" uniqKey="Jenne D">DE Jenne</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bai, Xh" uniqKey="Bai X">XH Bai</name></author><author><name sortKey="Wang, Dw" uniqKey="Wang D">DW Wang</name></author><author><name sortKey="Kong, L" uniqKey="Kong L">L Kong</name></author><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name></author><author><name sortKey="Luan, Y" uniqKey="Luan Y">Y Luan</name></author><author><name sortKey="Kobayashi, T" uniqKey="Kobayashi T">T Kobayashi</name></author><author><name sortKey="Kronenberg, Hm" uniqKey="Kronenberg H">HM Kronenberg</name></author><author><name sortKey="Yu, Xp" uniqKey="Yu X">XP Yu</name></author><author><name sortKey="Liu, Cj" uniqKey="Liu C">CJ Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Daniel, R" uniqKey="Daniel R">R Daniel</name></author><author><name sortKey="He, Z" uniqKey="He Z">Z He</name></author><author><name sortKey="Carmichael, Kp" uniqKey="Carmichael K">KP Carmichael</name></author><author><name sortKey="Halper, J" uniqKey="Halper J">J Halper</name></author><author><name sortKey="Bateman, A" uniqKey="Bateman A">A Bateman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Arai, T" uniqKey="Arai T">T Arai</name></author><author><name sortKey="Hasegawa, M" uniqKey="Hasegawa M">M Hasegawa</name></author><author><name sortKey="Akiyama, H" uniqKey="Akiyama H">H Akiyama</name></author><author><name sortKey="Ikeda, K" uniqKey="Ikeda K">K Ikeda</name></author><author><name sortKey="Nonaka, T" uniqKey="Nonaka T">T Nonaka</name></author><author><name sortKey="Mori, H" uniqKey="Mori H">H Mori</name></author><author><name sortKey="Mann, D" uniqKey="Mann D">D Mann</name></author><author><name sortKey="Tsuchiya, K" uniqKey="Tsuchiya K">K Tsuchiya</name></author><author><name sortKey="Yoshida, M" uniqKey="Yoshida M">M Yoshida</name></author><author><name sortKey="Hashizume, Y" uniqKey="Hashizume Y">Y Hashizume</name></author><author><name sortKey="Oda, T" uniqKey="Oda T">T Oda</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Neumann, M" uniqKey="Neumann M">M Neumann</name></author><author><name sortKey="Sampathu, Dm" uniqKey="Sampathu D">DM Sampathu</name></author><author><name sortKey="Kwong, Lk" uniqKey="Kwong L">LK Kwong</name></author><author><name sortKey="Truax, Ac" uniqKey="Truax A">AC Truax</name></author><author><name sortKey="Micsenyi, Mc" uniqKey="Micsenyi M">MC Micsenyi</name></author><author><name sortKey="Chou, Tt" uniqKey="Chou T">TT Chou</name></author><author><name sortKey="Bruce, J" uniqKey="Bruce J">J Bruce</name></author><author><name sortKey="Schuck, T" uniqKey="Schuck T">T Schuck</name></author><author><name sortKey="Grossman, M" uniqKey="Grossman M">M Grossman</name></author><author><name sortKey="Clark, Cm" uniqKey="Clark C">CM Clark</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baker, M" uniqKey="Baker M">M Baker</name></author><author><name sortKey="Mackenzie, Ir" uniqKey="Mackenzie I">IR Mackenzie</name></author><author><name sortKey="Pickering Brown, Sm" uniqKey="Pickering Brown S">SM Pickering-Brown</name></author><author><name sortKey="Gass, J" uniqKey="Gass J">J Gass</name></author><author><name sortKey="Rademakers, R" uniqKey="Rademakers R">R Rademakers</name></author><author><name sortKey="Lindholm, C" uniqKey="Lindholm C">C Lindholm</name></author><author><name sortKey="Snowden, J" uniqKey="Snowden J">J Snowden</name></author><author><name sortKey="Adamson, J" uniqKey="Adamson J">J Adamson</name></author><author><name sortKey="Sadovnick, Ad" uniqKey="Sadovnick A">AD Sadovnick</name></author><author><name sortKey="Rollinson, S" uniqKey="Rollinson S">S Rollinson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gijselinck, I" uniqKey="Gijselinck I">I Gijselinck</name></author><author><name sortKey="Van Broeckhoven, C" uniqKey="Van Broeckhoven C">C Van Broeckhoven</name></author><author><name sortKey="Cruts, M" uniqKey="Cruts M">M Cruts</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cruts, M" uniqKey="Cruts M">M Cruts</name></author><author><name sortKey="Gijselinck, I" uniqKey="Gijselinck I">I Gijselinck</name></author><author><name sortKey="Van Der Zee, J" uniqKey="Van Der Zee J">J van der Zee</name></author><author><name sortKey="Engelborghs, S" uniqKey="Engelborghs S">S Engelborghs</name></author><author><name sortKey="Wils, H" uniqKey="Wils H">H Wils</name></author><author><name sortKey="Pirici, D" uniqKey="Pirici D">D Pirici</name></author><author><name sortKey="Rademakers, R" uniqKey="Rademakers R">R Rademakers</name></author><author><name sortKey="Vandenberghe, R" uniqKey="Vandenberghe R">R Vandenberghe</name></author><author><name sortKey="Dermaut, B" uniqKey="Dermaut B">B Dermaut</name></author><author><name sortKey="Martin, Jj" uniqKey="Martin J">JJ Martin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Josephs, Ka" uniqKey="Josephs K">KA Josephs</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Snowden, Js" uniqKey="Snowden J">JS Snowden</name></author><author><name sortKey="Pickering Brown, Sm" uniqKey="Pickering Brown S">SM Pickering-Brown</name></author><author><name sortKey="Mackenzie, Ir" uniqKey="Mackenzie I">IR Mackenzie</name></author><author><name sortKey="Richardson, Am" uniqKey="Richardson A">AM Richardson</name></author><author><name sortKey="Varma, A" uniqKey="Varma A">A Varma</name></author><author><name sortKey="Neary, D" uniqKey="Neary D">D Neary</name></author><author><name sortKey="Mann, Dm" uniqKey="Mann D">DM Mann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gass, J" uniqKey="Gass J">J Gass</name></author><author><name sortKey="Cannon, A" uniqKey="Cannon A">A Cannon</name></author><author><name sortKey="Mackenzie, Ir" uniqKey="Mackenzie I">IR Mackenzie</name></author><author><name sortKey="Boeve, B" uniqKey="Boeve B">B Boeve</name></author><author><name sortKey="Baker, M" uniqKey="Baker M">M Baker</name></author><author><name sortKey="Adamson, J" uniqKey="Adamson J">J Adamson</name></author><author><name sortKey="Crook, R" uniqKey="Crook R">R Crook</name></author><author><name sortKey="Melquist, S" uniqKey="Melquist S">S Melquist</name></author><author><name sortKey="Kuntz, K" uniqKey="Kuntz K">K Kuntz</name></author><author><name sortKey="Petersen, R" uniqKey="Petersen R">R Petersen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cruts, M" uniqKey="Cruts M">M Cruts</name></author><author><name sortKey="Van Broeckhoven, C" uniqKey="Van Broeckhoven C">C Van Broeckhoven</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vossel, Ka" uniqKey="Vossel K">KA Vossel</name></author><author><name sortKey="Miller, Bl" uniqKey="Miller B">BL Miller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jellinger, Ka" uniqKey="Jellinger K">KA Jellinger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Williams, A" uniqKey="Williams A">A Williams</name></author><author><name sortKey="Jahreiss, L" uniqKey="Jahreiss L">L Jahreiss</name></author><author><name sortKey="Sarkar, S" uniqKey="Sarkar S">S Sarkar</name></author><author><name sortKey="Saiki, S" uniqKey="Saiki S">S Saiki</name></author><author><name sortKey="Menzies, Fm" uniqKey="Menzies F">FM Menzies</name></author><author><name sortKey="Ravikumar, B" uniqKey="Ravikumar B">B Ravikumar</name></author><author><name sortKey="Rubinsztein, Dc" uniqKey="Rubinsztein D">DC Rubinsztein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yin, F" uniqKey="Yin F">F Yin</name></author><author><name sortKey="Banerjee, R" uniqKey="Banerjee R">R Banerjee</name></author><author><name sortKey="Thomas, B" uniqKey="Thomas B">B Thomas</name></author><author><name sortKey="Zhou, P" uniqKey="Zhou P">P Zhou</name></author><author><name sortKey="Qian, L" uniqKey="Qian L">L Qian</name></author><author><name sortKey="Jia, T" uniqKey="Jia T">T Jia</name></author><author><name sortKey="Ma, X" uniqKey="Ma X">X Ma</name></author><author><name sortKey="Ma, Y" uniqKey="Ma Y">Y Ma</name></author><author><name sortKey="Iadecola, C" uniqKey="Iadecola C">C Iadecola</name></author><author><name sortKey="Beal, Mf" uniqKey="Beal M">MF Beal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kayasuga, Y" uniqKey="Kayasuga Y">Y Kayasuga</name></author><author><name sortKey="Chiba, S" uniqKey="Chiba S">S Chiba</name></author><author><name sortKey="Suzuki, M" uniqKey="Suzuki M">M Suzuki</name></author><author><name sortKey="Kikusui, T" uniqKey="Kikusui T">T Kikusui</name></author><author><name sortKey="Matsuwaki, T" uniqKey="Matsuwaki T">T Matsuwaki</name></author><author><name sortKey="Yamanouchi, K" uniqKey="Yamanouchi K">K Yamanouchi</name></author><author><name sortKey="Kotaki, H" uniqKey="Kotaki H">H Kotaki</name></author><author><name sortKey="Horai, R" uniqKey="Horai R">R Horai</name></author><author><name sortKey="Iwakura, Y" uniqKey="Iwakura Y">Y Iwakura</name></author><author><name sortKey="Nishihara, M" uniqKey="Nishihara M">M Nishihara</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Suzuki, M" uniqKey="Suzuki M">M Suzuki</name></author><author><name sortKey="Lee, Hc" uniqKey="Lee H">HC Lee</name></author><author><name sortKey="Kayasuga, Y" uniqKey="Kayasuga Y">Y Kayasuga</name></author><author><name sortKey="Chiba, S" uniqKey="Chiba S">S Chiba</name></author><author><name sortKey="Nedachi, T" uniqKey="Nedachi T">T Nedachi</name></author><author><name sortKey="Matsuwaki, T" uniqKey="Matsuwaki T">T Matsuwaki</name></author><author><name sortKey="Yamanouchi, K" uniqKey="Yamanouchi K">K Yamanouchi</name></author><author><name sortKey="Nishihara, M" uniqKey="Nishihara M">M Nishihara</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yin, F" uniqKey="Yin F">F Yin</name></author><author><name sortKey="Dumont, M" uniqKey="Dumont M">M Dumont</name></author><author><name sortKey="Banerjee, R" uniqKey="Banerjee R">R Banerjee</name></author><author><name sortKey="Ma, Y" uniqKey="Ma Y">Y Ma</name></author><author><name sortKey="Li, H" uniqKey="Li H">H Li</name></author><author><name sortKey="Lin, Mt" uniqKey="Lin M">MT Lin</name></author><author><name sortKey="Beal, Mf" uniqKey="Beal M">MF Beal</name></author><author><name sortKey="Nathan, C" uniqKey="Nathan C">C Nathan</name></author><author><name sortKey="Thomas, B" uniqKey="Thomas B">B Thomas</name></author><author><name sortKey="Ding, A" uniqKey="Ding A">A Ding</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ahmed, Z" uniqKey="Ahmed Z">Z Ahmed</name></author><author><name sortKey="Sheng, H" uniqKey="Sheng H">H Sheng</name></author><author><name sortKey="Xu, Yf" uniqKey="Xu Y">YF Xu</name></author><author><name sortKey="Lin, Wl" uniqKey="Lin W">WL Lin</name></author><author><name sortKey="Innes, Ae" uniqKey="Innes A">AE Innes</name></author><author><name sortKey="Gass, J" uniqKey="Gass J">J Gass</name></author><author><name sortKey="Yu, X" uniqKey="Yu X">X Yu</name></author><author><name sortKey="Hou, H" uniqKey="Hou H">H Hou</name></author><author><name sortKey="Chiba, S" uniqKey="Chiba S">S Chiba</name></author><author><name sortKey="Yamanouchi, K" uniqKey="Yamanouchi K">K Yamanouchi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Damme, P" uniqKey="Van Damme P">P Van Damme</name></author><author><name sortKey="Van Hoecke, A" uniqKey="Van Hoecke A">A Van Hoecke</name></author><author><name sortKey="Lambrechts, D" uniqKey="Lambrechts D">D Lambrechts</name></author><author><name sortKey="Vanacker, P" uniqKey="Vanacker P">P Vanacker</name></author><author><name sortKey="Bogaert, E" uniqKey="Bogaert E">E Bogaert</name></author><author><name sortKey="Van Swieten, J" uniqKey="Van Swieten J">J van Swieten</name></author><author><name sortKey="Carmeliet, P" uniqKey="Carmeliet P">P Carmeliet</name></author><author><name sortKey="Van Den Bosch, L" uniqKey="Van Den Bosch L">L Van Den Bosch</name></author><author><name sortKey="Robberecht, W" uniqKey="Robberecht W">W Robberecht</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ryan, Cl" uniqKey="Ryan C">CL Ryan</name></author><author><name sortKey="Baranowski, Dc" uniqKey="Baranowski D">DC Baranowski</name></author><author><name sortKey="Chitramuthu, Bp" uniqKey="Chitramuthu B">BP Chitramuthu</name></author><author><name sortKey="Malik, S" uniqKey="Malik S">S Malik</name></author><author><name sortKey="Li, Z" uniqKey="Li Z">Z Li</name></author><author><name sortKey="Cao, M" uniqKey="Cao M">M Cao</name></author><author><name sortKey="Minotti, S" uniqKey="Minotti S">S Minotti</name></author><author><name sortKey="Durham, Hd" uniqKey="Durham H">HD Durham</name></author><author><name sortKey="Kay, Dg" uniqKey="Kay D">DG Kay</name></author><author><name sortKey="Shaw, Ca" uniqKey="Shaw C">CA Shaw</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lieschke, Gj" uniqKey="Lieschke G">GJ Lieschke</name></author><author><name sortKey="Currie, Pd" uniqKey="Currie P">PD Currie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cadieux, B" uniqKey="Cadieux B">B Cadieux</name></author><author><name sortKey="Chitramuthu, Bp" uniqKey="Chitramuthu B">BP Chitramuthu</name></author><author><name sortKey="Baranowski, D" uniqKey="Baranowski D">D Baranowski</name></author><author><name sortKey="Bennett, Hp" uniqKey="Bennett H">HP Bennett</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shankaran, Ss" uniqKey="Shankaran S">SS Shankaran</name></author><author><name sortKey="Capell, A" uniqKey="Capell A">A Capell</name></author><author><name sortKey="Hruscha, At" uniqKey="Hruscha A">AT Hruscha</name></author><author><name sortKey="Fellerer, K" uniqKey="Fellerer K">K Fellerer</name></author><author><name sortKey="Neumann, M" uniqKey="Neumann M">M Neumann</name></author><author><name sortKey="Schmid, B" uniqKey="Schmid B">B Schmid</name></author><author><name sortKey="Haass, C" uniqKey="Haass C">C Haass</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Feldner, J" uniqKey="Feldner J">J Feldner</name></author><author><name sortKey="Reimer, Mm" uniqKey="Reimer M">MM Reimer</name></author><author><name sortKey="Schweitzer, J" uniqKey="Schweitzer J">J Schweitzer</name></author><author><name sortKey="Wendik, B" uniqKey="Wendik B">B Wendik</name></author><author><name sortKey="Meyer, D" uniqKey="Meyer D">D Meyer</name></author><author><name sortKey="Becker, T" uniqKey="Becker T">T Becker</name></author><author><name sortKey="Becker, Cg" uniqKey="Becker C">CG Becker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mcwhorter, Ml" uniqKey="Mcwhorter M">ML McWhorter</name></author><author><name sortKey="Monani, Ur" uniqKey="Monani U">UR Monani</name></author><author><name sortKey="Burghes, Ah" uniqKey="Burghes A">AH Burghes</name></author><author><name sortKey="Beattie, Ce" uniqKey="Beattie C">CE Beattie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Feldner, J" uniqKey="Feldner J">J Feldner</name></author><author><name sortKey="Becker, T" uniqKey="Becker T">T Becker</name></author><author><name sortKey="Goishi, K" uniqKey="Goishi K">K Goishi</name></author><author><name sortKey="Schweitzer, J" uniqKey="Schweitzer J">J Schweitzer</name></author><author><name sortKey="Lee, P" uniqKey="Lee P">P Lee</name></author><author><name sortKey="Schachner, M" uniqKey="Schachner M">M Schachner</name></author><author><name sortKey="Klagsbrun, M" uniqKey="Klagsbrun M">M Klagsbrun</name></author><author><name sortKey="Becker, Cg" uniqKey="Becker C">CG Becker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tessier Lavigne, M" uniqKey="Tessier Lavigne M">M Tessier-Lavigne</name></author><author><name sortKey="Goodman, Cs" uniqKey="Goodman C">CS Goodman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ozdinler, Ph" uniqKey="Ozdinler P">PH Ozdinler</name></author><author><name sortKey="Macklis, Jd" uniqKey="Macklis J">JD Macklis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sanchez Camacho, C" uniqKey="Sanchez Camacho C">C Sanchez-Camacho</name></author><author><name sortKey="Rodriguez, J" uniqKey="Rodriguez J">J Rodriguez</name></author><author><name sortKey="Ruiz, Jm" uniqKey="Ruiz J">JM Ruiz</name></author><author><name sortKey="Trousse, F" uniqKey="Trousse F">F Trousse</name></author><author><name sortKey="Bovolenta, P" uniqKey="Bovolenta P">P Bovolenta</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Eggert, C" uniqKey="Eggert C">C Eggert</name></author><author><name sortKey="Chari, A" uniqKey="Chari A">A Chari</name></author><author><name sortKey="Laggerbauer, B" uniqKey="Laggerbauer B">B Laggerbauer</name></author><author><name sortKey="Fischer, U" uniqKey="Fischer U">U Fischer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kruger, Rp" uniqKey="Kruger R">RP Kruger</name></author><author><name sortKey="Aurandt, J" uniqKey="Aurandt J">J Aurandt</name></author><author><name sortKey="Guan, Kl" uniqKey="Guan K">KL Guan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Alias, L" uniqKey="Alias L">L Alias</name></author><author><name sortKey="Bernal, S" uniqKey="Bernal S">S Bernal</name></author><author><name sortKey="Fuentes Prior, P" uniqKey="Fuentes Prior P">P Fuentes-Prior</name></author><author><name sortKey="Barcelo, Mj" uniqKey="Barcelo M">MJ Barcelo</name></author><author><name sortKey="Also, E" uniqKey="Also E">E Also</name></author><author><name sortKey="Martinez Hernandez, R" uniqKey="Martinez Hernandez R">R Martinez-Hernandez</name></author><author><name sortKey="Rodriguez Alvarez, Fj" uniqKey="Rodriguez Alvarez F">FJ Rodriguez-Alvarez</name></author><author><name sortKey="Martin, Y" uniqKey="Martin Y">Y Martin</name></author><author><name sortKey="Aller, E" uniqKey="Aller E">E Aller</name></author><author><name sortKey="Grau, E" uniqKey="Grau E">E Grau</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Corcia, P" uniqKey="Corcia P">P Corcia</name></author><author><name sortKey="Camu, W" uniqKey="Camu W">W Camu</name></author><author><name sortKey="Praline, J" uniqKey="Praline J">J Praline</name></author><author><name sortKey="Gordon, Ph" uniqKey="Gordon P">PH Gordon</name></author><author><name sortKey="Vourch, P" uniqKey="Vourch P">P Vourch</name></author><author><name sortKey="Andres, C" uniqKey="Andres C">C Andres</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yin, F" uniqKey="Yin F">F Yin</name></author><author><name sortKey="Dumont, M" uniqKey="Dumont M">M Dumont</name></author><author><name sortKey="Banerjee, R" uniqKey="Banerjee R">R Banerjee</name></author><author><name sortKey="Ma, Y" uniqKey="Ma Y">Y Ma</name></author><author><name sortKey="Li, H" uniqKey="Li H">H Li</name></author><author><name sortKey="Lin, Mt" uniqKey="Lin M">MT Lin</name></author><author><name sortKey="Beal, Mf" uniqKey="Beal M">MF Beal</name></author><author><name sortKey="Nathan, C" uniqKey="Nathan C">C Nathan</name></author><author><name sortKey="Thomas, B" uniqKey="Thomas B">B Thomas</name></author><author><name sortKey="Ding, A" uniqKey="Ding A">A Ding</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sleegers, K" uniqKey="Sleegers K">K Sleegers</name></author><author><name sortKey="Brouwers, N" uniqKey="Brouwers N">N Brouwers</name></author><author><name sortKey="Maurer Stroh, S" uniqKey="Maurer Stroh S">S Maurer-Stroh</name></author><author><name sortKey="Van Es, Ma" uniqKey="Van Es M">MA van Es</name></author><author><name sortKey="Van Damme, P" uniqKey="Van Damme P">P Van Damme</name></author><author><name sortKey="Van Vught, Pw" uniqKey="Van Vught P">PW van Vught</name></author><author><name sortKey="Van Der Zee, J" uniqKey="Van Der Zee J">J van der Zee</name></author><author><name sortKey="Serneels, S" uniqKey="Serneels S">S Serneels</name></author><author><name sortKey="De Pooter, T" uniqKey="De Pooter T">T De Pooter</name></author><author><name sortKey="Van Den Broeck, M" uniqKey="Van Den Broeck M">M Van den Broeck</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kabashi, E" uniqKey="Kabashi E">E Kabashi</name></author><author><name sortKey="Lin, L" uniqKey="Lin L">L 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Chitramuthu</name></noRegion><name sortKey="Baranowski, David C" sort="Baranowski, David C" uniqKey="Baranowski D" first="David C" last="Baranowski">David C. Baranowski</name><name sortKey="Bateman, Andrew" sort="Bateman, Andrew" uniqKey="Bateman A" first="Andrew" last="Bateman">Andrew Bateman</name><name sortKey="Bennett, Hugh Pj" sort="Bennett, Hugh Pj" uniqKey="Bennett H" first="Hugh Pj" last="Bennett">Hugh Pj Bennett</name><name sortKey="Chitramuthu, Babykumari P" sort="Chitramuthu, Babykumari P" uniqKey="Chitramuthu B" first="Babykumari P" last="Chitramuthu">Babykumari P. Chitramuthu</name><name sortKey="Kay, Denis G" sort="Kay, Denis G" uniqKey="Kay D" first="Denis G" last="Kay">Denis G. Kay</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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